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     THE CANCER BUSINESS
                                       
   
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  The same companies that profit from breast cancer treatments also manufacture
  cancer-causing toxins.
  
  by Monte Paulsen 
  
   
   
   Here in the United States, where health care is a business rather than
   a right, the 182,000 women stricken by breast cancer annually are not
   only an epidemic, but also a market opportunity.
   
   The market is dominated by some of the world's largest
   corporations --many of which also produce and release the toxic
   organochlorine chemicals now suspected of causing breast cancer. These
   companies have a vested financial interest in keeping breast cancer
   research and advocacy pointed away from possible causes such as
   corporate pollution and focused on the profitable businesses of cancer
   detection and treatment.
   
   The relationships between these corporations and such organizations as
   the federally funded National Cancer Institute and the nonprofit
   American Cancer Society are complex, but many argue that industry has
   undue influence over the direction of cancer research. Here are a few
   troubling examples:
   
   Cures and causes. United Kingdom-based Zeneca Group PLC is the
   undisputed leader in the breast cancer business, selling $470 million
   a year of a controversial treatment drug called Nolvadex. Zeneca also
   sells a carcinogenic herbicide called acetochlor, whose market is
   estimated at $300 million annually. The company has been in hot water
   for allegedly releasing organochlorines into the environment in 1990
   Zeneca (then a branch of Imperial Chemical Industries, from which it
   demerged in June 1993) was named in a lawsuit by federal and state
   governments for allegedly dumping DDT and PCBs into Los Angeles and
   Long Beach harbors. (The suit is pending.)
   
   Nolvadex is Zeneca's trade name for tamoxifen citrate, a synthetic
   hormone. Tamoxifen is not a cure for breast cancer --it helps prevent
   recurrences in women who have been successfully treated for the
   disease. But tamoxifen is also thought to cause uterine cancer and a
   number of other health problems. In a study at the University of
   Pittsburgh that began in 1981, 23 of the approximately 4,000 women
   given tamoxifen contracted uterine cancer (as opposed to two from the
   control group), and four of them died of it.
   
   It is not clear how long Bernard Fisher, the lead scientist in the
   study, knew of the uterine-cancer deaths. But until recently, women
   volunteering for Fisher's new Breast Cancer Prevention Trial of
   tamoxifen were told that o deaths from uterine cancer were reported
   as a result of the earlier study. (On March 29, Fisher stepped down as
   principal investigator of 14 federally funded studies. He had been
   heavily criticized for his delays in disclosing research fraud in
   several breast cancer studies, at least two of which recommended
   tamoxifen.)
   
   Recruitment of additional women into the prevention trial has been
   temporarily halted, but the National Cancer Institute continues to
   spend millions of taxpayer dollars giving tamoxifen to women who don't
   have breast cancer to see if it will prevent them from developing the
   disease. Tamoxifen is already the world's best-selling cancer drug,
   but if it is approved for use as a prevention drug, Zeneca will be
   able to increase sales dramatically.
   
   Zeneca is not alone in simultaneously releasing organochlorines into
   the environment and selling questionable and potentially dangerous
   breast cancer treatments. Du Pont and General Electric, which compete
   for the dubious distinction of having the highest number of EPA
   Superfund hazardous waste sites, are also big players in the breast
   cancer business. GE sells more than $100 million a year of mammography
   machines, while Du Pont makes much of the film used in those machines.
   
   
   There are about 14,000 mammography machines installed in the United
   States. That's two to three times more than are needed, according to
   an analysis by the National Cancer Institute. Those machines perform
   about 24 million mammograms a year, nine out of 10 of which are
   routine screenings performed on asymptomatic women. Several scientific
   studies suggest that such routine mammography does not benefit women
   under 50, and some researchers propose that it may actually increase
   breast cancer risk. (See sidebar, opposite.)
   
   Still, both Du Pont and GE aggressively market mammography to younger
   women. A Du Pont TV ad even boasts that the company's new film akes
   it safer to start mammography early.
   
   Although the National Cancer Institute recently stopped advising
   mammograms for women under 50, the American Cancer Society (to which
   both Du Pont and GE contribute) continues to advise women to have
   screening mammograms in their 40s.
   
   Cancerous politics. Almost 15 years ago, in his book he Cancer
   Syndrome, Ralph Moss described the complex arrangement of
   interlocking committees, boards of directors, funding, and investments
   that enable industry to exert substantial influence over cancer
   research and advocacy. The types of conflict of interest which Moss
   described are still in effect today, as are a few new ones.
   
   Zeneca is a pioneer in new ways of influencing breast cancer activism.
   Take the example of the 10-year-old National Breast Cancer Awareness
   Month, which causes a talk-show frenzy each October and is supported
   by both the National Cancer Institute and the American Cancer Society.
   Few realize that Zeneca is the founder and sole financial sponsor of
   awareness month, and has spent several million dollars on the event.
   And the message awareness month spreads via hundreds of thousands of
   posters, pamphlets, radio spots, newspaper ads, and promotional
   videos? arly detection is your best prevention . . . get a mammogram
   now.
   
   This year, Zeneca is turning its attention to the workplace. Together
   with fellow pharmaceutical makers Glaxo and Merck, Zeneca launched the
   Industries Coalition Against Cancer in April. Its goal is to
   encourage corporations to invest in ancer screening/prevention
   programs such as  mammography unit on site, a mobile van program,
   or perhaps a partnership with a cancer center.
   
   Through these forays into pseudo-activism, companies like Zeneca have
   made treatment, rather than root causes, the issue. The bottom line is
   this: There's little profit in preventing breast cancer.
   
   Monte Paulsen is a reporter living in South Carolina. Research
   assistance was provided by Anna Snider. All Rights Reserved.